Elle's quest takes her to the irradiated city of Las Vegas, a sand-choked ghost-town of forgotten memories following the detonation of a dirty bomb.

There she finds a community of Replicants, abandoned hospitality models from the old casinos now living as embodiments of ancient Egyptian and Roman royalty. Meanwhile, Niander Wallace, smarting from his last encounter with Elle, has dispatched a seasoned kill team to bring back her head.